Hemostasis

Thrombopoiesis

Megakaryocytes differentiate from myeloid stem cell and are responsible for production of platelets.

Three stages of maturation Megakaryocytes.

Basophilic stage, megakaryocyte is small, has diploid nucleus and abundant basophilic cytoplasm

Granular stage, here the nucleus is more polypoid, cytoplasm is more eosinophilic and granular.

Mature stage, megakaryocyte is very large, with approx 16-32 nuclei, abundance of granular cytoplasm. It undergoes shedding to form 

platelets